disease, ailment
痡 centers on the state of being unwell: a disease or ailment that causes suffering.
痡 combines the sickness radical 疒 with 甫, which likely provides the sound. The exact historical development is uncertain, but the structure suggests a phono-semantic compound related to illness.
The sickness enclosure 疒 surrounds 甫, like an ailment taking hold inside the body. Picture a disease spreading within.
For ホ, imagine a person with a disease letting out a hoarse cough: ho -> ホ, and the sickness enclosure 疒 shows the illness.