noun, noun or participle which takes 'suru', intransitive verb
A somewhat literary or formal word for deep emotional pain or worry. Often used in the pattern 痛心に堪えない (cannot bear the heartache).
彼の死を聞いて痛心に堪えなかった。
I could not bear the heartache upon hearing of his death.
その知らせは彼女に深い痛心をもたらした。
The news brought her deep anguish.