calico cat; tortoiseshell-and-white cat
A domestic cat with a tri-color coat of white, orange, and black (or their dilute versions). In Japanese, 三毛猫 specifically refers to the calico pattern, which is almost always female due to genetics.
Our calico cat is very friendly.
Male calico cats are extremely rare.
白猫 is a solid white cat, whereas 三毛猫 has a tri-color pattern.
From 三毛 (みけ, 'three fur colors') + 猫 (ねこ, 'cat'). The term directly describes the cat's tri-color coat.