adverb
Expresses strong exasperation or being at one's wit's end; often used with verbs like 困る, 呆れる, 嫌になる.
彼の無責任さにはほとほと困っている。
I'm utterly fed up with his irresponsibility.
毎日同じことの繰り返しで、ほとほと嫌になった。
I'm completely sick of doing the same thing every day.