Expresses strong exasperation or being at one's wit's end; often used with verbs like 困る, 呆れる, 嫌になる.
I'm utterly fed up with his irresponsibility.
毎日同じことの繰り返しで、ほとほと嫌になった。
I'm completely sick of doing the same thing every day.
I'm at my wit's end with his selfishness.
I got utterly sick of hearing the same complaint over and over.
I was utterly appalled by his excuses.
I became utterly exhausted by the drawn-out negotiations.