after all; in the end; when all is said and done
A somewhat formal or literary expression used to state a conclusion after considering everything. Often interchangeable with 結局 or 要するに, but carries a more classical tone.
I tried various things, but in the end I didn't succeed.
彼の主張は、畢竟するに自己中心的なものだった。
His argument, after all, was self-centered.
From the kanji 畢竟 (ひっきょう, 'after all') combined with するに, a classical phrasing meaning 'when it comes to'. The exact historical derivation is uncertain, but it functions as a fixed adverbial expression.