car sickness; motion sickness in a car
Refers specifically to motion sickness experienced while riding in a car.
長距離ドライブで車酔いしてしまった。
I got car sick on the long drive.
車酔いしやすいので、酔い止めを飲んでから乗ります。
I get car sick easily, so I take motion sickness medicine before riding.
Compound of 車 (car) and 酔い (sickness, intoxication). The exact historical derivation is uncertain, but the word transparently means 'car sickness'.