noun
all worldly affairs; everything in life
A somewhat literary or formal expression referring to all the practical matters and concerns of daily life. Often used in contexts of detachment or broad perspective.
彼は世事一切に無関心で、研究だけに没頭している。
He is indifferent to all worldly affairs and devotes himself solely to his research.
世事一切を捨てて隠遁生活に入る。
Abandon all worldly matters and enter a life of seclusion.
Compound of 世事 (worldly affairs) and 一切 (all, everything). The exact historical derivation is uncertain, but the combination is transparently formed from these two elements.