expression
at any rate; anyhow; anyway; in any case; because
Used to introduce a conclusion or reason regardless of circumstances. Similar to 何しろ and 何にせよ, but 何にしろ is slightly more formal than 何しろ.
See also: 何しろ (なにしろ) · 何にせよ (なんにせよ)
何にしろ、まずはやってみよう。
Anyway, let's give it a try first.
何にしろ彼が来るなら準備が必要だ。
In any case, if he's coming we need to prepare.