noun
disposition; inclination; propensity
Refers to a person's natural tendency, habit, or characteristic way of thinking/behaving, often with a slightly negative or peculiar connotation.
彼には嘘をつく性癖がある。
He has a propensity for lying.
彼女の几
Her meticulous disposition serves her well at work.
noun
sexual disposition; fetish
Colloquial use referring specifically to sexual preferences or kinks.
彼は変わった性癖の持ち主だ。
He has unusual sexual tastes.