expression, suru verb (irregular)
hate the very sight of; hold a grudge against; treat as an enemy; have it in for
Idiomatic expression meaning to intensely dislike someone and treat them as a target of hostility, often for petty or persistent reasons. Used with を to mark the person hated.
彼はなぜか私を目の敵にする。
For some reason, he has it in for me.
上司に目の敵にされて、会
My boss treats me like an enemy, so it's hard to go to work.