noun
Refers to the effort, trouble, or hard work one puts into something, often with a nuance of going out of one's way. Common in phrases like 骨折り損 (wasted effort) and 骨折り甲斐 (reward for one's effort).
彼の骨折りで、プロジェクトは成功した。
Thanks to his efforts, the project was a success.
It was all wasted effort for nothing.