Related words· 6 それでも is a neutral 'even so', while それなのに adds a stronger sense of surprise or frustration at the unexpected contrast.
しかし is a general, formal/written 'however', whereas それなのに is more conversational and emphasizes emotional contradiction with what was just said.
だが is a blunt, somewhat literary 'but', while それなのに is softer in tone but carries more feeling of disappointment or disbelief.
それなのに is casual and often expresses surprise or complaint, while それにもかかわらず is neutral and suited to formal or written contrast.
Show 2 more Show fewer それなのに is a straightforward contrastive conjunction ('and yet'), while しかも in its contrastive sense usually carries a stronger tone of irony or surprise.
それなのに is more colloquial and often carries stronger emotion or complaint, while それでいて is slightly more formal and descriptive.
Etymology Compound of それ (that) + なのに (and yet, despite that). なのに is itself a combination of the copula な and the contrastive particle のに .
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