and yet; but even so; nevertheless
Expresses a contrast with what was just said, often with a feeling of surprise, disappointment, or frustration. Similar to それでも but with a stronger sense of 'despite that being the case'.
He studied very hard. And yet, he failed the exam.
天気予報は晴れだった。それなのに、急に雨が降り出した。
The weather forecast said it would be sunny. But even so, it suddenly started raining.