Kanji 関 connection, barrier, gateway 拘 arrest, seize, concerned Related words それなのに is casual and often expresses surprise or complaint, while それにもかかわらず is neutral and suited to formal or written contrast.
にもかかわらず attaches directly after a noun or clause without それ , whereas それにもかかわらず stands alone as a sentence-initial connector referring back to the previous statement.
しかし is a general-purpose word for 'however' usable in any contrast, while それにもかかわらず specifically stresses that the following fact is unexpected given what preceded.
Written forms それにも 関かか わらず
Kanji spelling using 関わる ; less common but still seen.
それにも 拘かか わらず
Kanji spelling using 拘わる ; less common than the kana form.
Etymology Compound of それ (that) + に (particle) + も (also) + かかわらず (negative te-form of 拘わる , 'to be concerned with'). Literally 'without being concerned with that', it developed into a conjunction meaning 'nevertheless'.
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