〈体からだの部ぶ分ぶん〉がキリキリ痛いたむfor a body part to hurt with a sharp, stabbing pain
緊きん張ちょうすると胃いがキリキリ痛いたむ。
When I get nervous, my stomach hurts with a sharp, stabbing pain.
〈物もの〉をキリキリ締しめるto pull or tighten something firmly and tensely
ロープをキリキリと締しめて荷に物もつを固こ定ていした。
I pulled the rope tight and secured the luggage.
歯はをキリキリ鳴ならすto grind one's teeth (making a sharp grinding sound)
彼かれは寝ねている間あいだに歯はをキリキリ鳴ならす。
He grinds his teeth while he's sleeping.
〈物もの〉がキリキリ回まわるfor something to spin around rapidly (often with a whirring sound)
風かざ車ぐるまがキリキリと勢いきおいよく回まわっている。
The pinwheel is spinning around rapidly.
キリキリ働はたらくto work briskly and efficiently
彼かの女じょは朝あさからキリキリと働はたらいている。
She has been working briskly since morning.

Related words

ぎゅっと sense 2
キリキリ describes winding or pulling something tight with a sense of tension or creaking, while ぎゅっと simply describes a firm, single squeeze or grip.
くるくるN1sense 3
キリキリ describes fast, sometimes creaking spinning, while くるくる is the more neutral word for something turning round and round.
しくしくN1sense 4
キリキリ describes a sharp, stabbing pain (as in a stomach ache), while しくしく describes a dull, lingering ache.
きびきびN2sense 5
キリキリ working suggests brisk activity with a slight sense of pressure or urgency, while きびきび emphasizes crisp, energetic movement without that tension.
ずきずきN1
きりきり describes a sharp, twisting or cramping pain (often in the stomach), while ずきずき describes a throbbing, pulsing pain.

Don't confuse with

ぎりぎり
キリキリ and ギリギリ sound alike, but キリキリ describes grinding, binding, or sharp pain, while ギリギリ usually means 'barely' or 'right at the limit'.

Mimetic word; the exact origin is uncertain, but it is likely sound-symbolic, imitating a sharp, continuous sound or sensation.