Refers to the central business or commercial district of a city, often used in the context of American or Western cities. In Japanese, it may also be used for entertainment districts modeled after Western downtowns.
週末はダウンタウンで買い物を楽しんだ。
I enjoyed shopping downtown over the weekend.
ダウンタウンには高層ビルが立ち並んでいる。
Skyscrapers line the downtown area.
On the weekend I went downtown with a friend to go shopping.
Many young people hang out downtown at night.