Used to indicate the second item in an ordered list or sequence. Often followed by に to mean 'secondly'.
He arrived second.
The second problem is difficult.
セカンド is a loanword prenominal adjective meaning 'second', while 二番目 is the native Japanese equivalent used more broadly in everyday speech.
二番目 is the colloquial, concrete way to say 'the second one' in a list, while 第二 is used in more formal or abstract, categorical contexts.
二番目 is the more common word for ranking or order in a list, while 二つ目 uses the generic つ counter and is typical for informal counting of items or points.
二番目 explicitly marks ordinal position ('the second one in a series'), whereas 二番 is often used as a plain label (e.g. the second verse of a song, a sumo bout number) without emphasizing sequence.
Standard kanji spelling.
Mixed kanji-kana spelling, less common but still used.
Spelling with Arabic numeral 2, common in informal writing.
Compound of 二 (ni, 'two') + 番 (ban, 'number') + 目 (me, ordinal suffix).