no matter what; at all costs; by any means
Expresses strong determination to achieve something regardless of difficulty or obstacles. Often used with volitional or imperative forms.
何としても明日までにこの仕事を終わらせなければならない。
I must finish this work by tomorrow no matter what.
彼は何としてもその試合に勝ちたいと思
He wants to win that match at all costs.
A fixed phrase combining the interrogative 何 (what) with the quotative と and the particle も, literally 'even as what', yielding the meaning 'no matter what'.