noun
heavy loss; great damage
Refers to substantial financial loss, physical destruction, or serious harm. Often used in business, disaster, or accident contexts.
台風で農家は大損害を受けた。
The farmers suffered great damage from the typhoon.
その投資の失敗で会社は大損害を被った。
The company incurred a heavy loss due to that investment failure.
大打撃 also means 'heavy blow' or 'severe damage', but is more figurative and often used for psychological or reputational impact, whereas 大損害 is more concrete and often financial or physical.
Compound of 大 (dai, 'big, great') + 損害 (songai, 'damage, loss'). The reading is the standard on'yomi combination.