なしに（は）・
なしに（は）・なしでは presents something as indispensable: without it, the following result cannot hold or cannot properly occur. The result therefore normally has an explicit or clearly understood negative meaning.
How it works
The noun before the construction names a required condition, resource, agreement, process, or support. The following clause then says that a result is impossible, difficult, invalid, or unable to function without it. This logical link—not mere absence—is the heart of the pattern.
With nouns
The negative result may be direct, such as “cannot accept,” or broader, such as “is difficult” or “will not function.”
適切な検証なしでは、この結論を受け入れることはできない。
Without proper verification, this conclusion cannot be accepted.
Analyze住民の理解なしには、この再開発計画を進めることは難しい。
Without the residents’ understanding, it would be difficult to proceed with this redevelopment plan.
Analyze専門家の助言なしに、この装置を安全に運用することはできない。
This equipment cannot be operated safely without expert advice.
AnalyzeWhen the required condition is an action
For an action that must happen first, place its dictionary form before ことなしには or ことなしでは.
Three boundaries to keep clear
ことなしに can elsewhere simply describe doing one action without doing another; on this page, it specifically marks an action required for a result that cannot otherwise occur. なくしては expresses the same broad logic of indispensability but sounds more forceful and rhetorical. 抜きに can merely mean omitting or excluding something, whereas なしでは says that the following result cannot stand without it.
More examples
十分な準備なしでは、長期の調査を完遂することは難しい。
Without adequate preparation, it is difficult to complete a long-term investigation.
Analyze社会の信頼なしには、この制度は機能しない。
This system will not function without public trust.
Analyze事前に影響を検討することなしには、責任ある判断は下せない。
A responsible decision cannot be made without examining the effects in advance.
Analyze関係者の協力なしに、期限内の復旧は望めない。
Recovery by the deadline cannot be expected without the cooperation of those involved.
Analyze原資料を確認することなしでは、その主張の妥当性を評価できない。
The validity of that claim cannot be assessed without checking the original materials.
Analyze継続的な資金援助なしには、研究を維持することは不可能だ。
It is impossible to sustain the research without continued financial support.
Analyze