noun which may take the genitive case particle 'no', na-adjective, adverb, adverb taking the 'to' particle
crumpled; rumpled; wrinkled; tousled
Describes paper, cloth, hair, etc. that is crushed, wrinkled, or in a messy, disheveled state. Often used with なる or する.
ポケットに入れていた紙がくしゃくしゃになった。
The paper I had in my pocket got crumpled.
He showed up at the meeting with tousled hair.
noun or participle which takes 'suru', adverb
Describes a mental state of irritation or frustration, often with する. The image is of one's feelings being crumpled.
彼の無責任な態度に気持ちがくしゃくしゃした。
I felt irritated by his irresponsible attitude.
adverb, adverb taking the 'to' particle
Mimetic for the sound of chewing noisily or crunching. Often used with 噛む.
彼はガムをくしゃくしゃ噛みながら話した。
He talked while noisily chewing gum.