worldly-wise; skilled at navigating life; knowing how to get on in the world
Describes a person who is adept at handling practical affairs, social situations, and life's challenges; often implies shrewdness or savvy.
He is worldly-wise and quickly fits into any workplace.
People who are skilled at navigating life skillfully avoid interpersonal troubles.
Compound of 処世 (shosei, 'conduct in life') and 上手 (jōzu, 'skillful').