godan verb (-su), transitive verb
General sense of depleting a resource or supply. Can be used for concrete things like money or abstract things like patience.
資金を尽かしてしまった。
We used up all our funds.
彼は才能を尽かし
It's not that he exhausted his talent.
godan verb (-su), transitive verb
give up on; lose patience with; be fed up with
Almost exclusively used in the set phrase 愛想を尽かす, meaning to become completely disgusted or fed up with someone and cut ties. The literal sense is 'to exhaust one's amiability'.
See also: 愛想を尽かす
彼の無責任さに愛想を尽かした。
I got fed up with his irresponsibility and gave up on him.