noun, noun or participle which takes 'suru', intransitive verb, noun which may take the genitive case particle 'no'
worry; mental agony; heartache
Refers to deep emotional distress, worry, or anguish. Can be used as a noun, with する to mean 'to worry deeply', or as a no-adjective.
彼の病気の知らせを聞いて、心痛のあまり眠れなかった。
Upon hearing the news of his illness, I was so worried I couldn't sleep.
彼女は将来のことでひどく心痛している。
She is deeply worried about the future.