expression, ichidan verb
use up all energy and willpower; be utterly exhausted and lose the will to go on
Describes a state of complete physical and mental exhaustion where one's drive or motivation is also depleted. Often used in literary or dramatic contexts.
彼は長い闘病生活で精根尽き果ててしまった。
After a long battle with illness, he used up all his energy and willpower.
過酷
After grueling labor, he collapsed as if completely spent in body and spirit.