薬やく石せき効こう無なく

adverb

no medical treatment having proved effective

A formal, somewhat literary set phrase used when all medical efforts have failed, often in contexts of terminal illness or death.

• 祖そ父ふは長ながい闘とう病びょうの末すえ、薬やく石せき効こう無なく亡なくなった。

  After a long illness, my grandfather passed away with no medical treatment having proved effective.