noun
giving up; being at a loss; throwing in the towel
Expresses a state of helplessness or resignation when one has exhausted all options. Often used in the phrase お手上げだ or お手上げになる. The literal image is of raising one's hands in surrender.
この問題は難しすぎて、もうお手上げだ。
This problem is too difficult; I'm completely at a loss.
彼
His stubbornness has me throwing up my hands.