Standard kanji spelling using 邪魔 (nuisance) and 虫 (bug/person).
おじゃま虫
Mixed kana-kanji spelling; common in casual writing.
Etymology
Compound of お (honorific prefix) + 邪魔 (nuisance, hindrance) + 虫 (bug, used figuratively for a person with a certain trait). The exact origin is uncertain, but it likely arose as a humorous, colloquial expression.