US Department of State; State Department
Refers specifically to the United States Department of State. Not used for state-level departments in other countries.
国務省は新しいビザ政策を発表した。
The State Department announced a new visa policy.
国務省 refers to the US Department of State, while 外務省 is Japan's own Ministry of Foreign Affairs, so they should not be used interchangeably.
国務省 (the State Department) handles US foreign diplomacy, whereas 国防省 (the Department of Defense) handles US military affairs, so learners should not mix them up.
Compound of 国務 (national affairs) and 省 (ministry/department).