mistress of the house; hostess; landlady; proprietress
Refers to a woman who is the head of a household, or who runs an inn, restaurant, or similar establishment. The specific English gloss depends on context.
The landlady of the inn greeted us at the entrance.
彼女はこの家の女主人として、使用人たちをよくまとめている。
As the mistress of this house, she manages the servants well.