Refers to a residential institution for children whose parents are deceased or unable to care for them. The term is neutral and widely understood.
彼は孤児院で育った。
He grew up in an orphanage.
その孤児院は多くの子供たちを支援している。
That orphanage supports many children.
He grew up in an orphanage as a child.
The mother had reasons to leave her child at the orphanage.
The organization operates an orphanage in the community.
Having lost her parents, she entered an orphanage.