also: きちげぇ
noun
madness; insanity; crazy person; lunatic
Derogatory and highly sensitive term for mental illness or a person perceived as insane. Strongly offensive; avoid in polite conversation. Often used hyperbolically or as an insult.
あんなことを言うなんて、きちがいじみている。
Saying something like that is crazy (literally: seems like madness).
彼は怒ると手がつけられないきちがいになる。
When he gets angry, he turns into an uncontrollable madman.
noun, noun, used as a suffix
mania; craze; obsession; enthusiast; fanatic
Used as a suffix or standalone noun to indicate an extreme obsession or enthusiast. Often derogatory or self-deprecating, e.g., 釣りきちがい (fishing nut). Less sensitive than sense 1 but still informal and potentially offensive.
彼は筋トレきちがいで、毎日ジムに通っている。
He's a workout fanatic and goes to the gym every day.
あの人はゲームきちがいだから、話が合うよ。
That person is a game maniac, so you'll get along.