致ち命めい的てき

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Meanings

Describes something that causes death or irreversible ruin; also used figuratively for a critical flaw or mistake that leads to failure.

致ち命めい的てきな〈物もの〉a fatal/critical (flaw, mistake, wound, etc.)
このプログラムには致ち命めい的てきな欠けっ陥かんがある。
This program has a fatal flaw.
〈物もの〉に致ち命めい的てきな打だ撃げきを与あたえるto deal a fatal/crippling blow to something
その事じ件けんは会かい社しゃの信しん用ように致ち命めい的てきな打だ撃げきを与あたえた。
The incident dealt a fatal blow to the company's credibility.
〈事こと〉が致ち命めい的てきになるfor something (e.g. a mistake) to become fatal or critical
小ちいさなミスが致ち命めい的てきになることもある。
A small mistake can sometimes turn out to be fatal.

命いのち取とり
命取り is a noun naming the fatal cause itself (often concrete, like an illness or habit), while 致命的 is an adjective describing something as fatal or critically damaging.
重じゅう大だいN3
重大 means serious or grave in a general sense, while 致命的 specifically implies that the seriousness leads to death or irreversible ruin.
深しん刻こくN3
深刻 describes a situation as deeply serious or troubling in an emotional or social sense, whereas 致命的 stresses that the damage cannot be undone.
致ち死し
致死 specifically means causing actual death and is mainly used in formal/legal/medical compounds like 致死量, while 致命的 is broader and can describe anything disastrous or decisive even without literal death.
末まっ期き的てきN1
致命的 focuses on something being fatal or decisive in its effect, whereas 末期的 emphasizes being in the final, terminal stage of a decline.

軽けい微び
軽微 describes a flaw, injury, or error as minor and insignificant, the opposite of 致命的 describing something as fatal or ruinous.

決けっ定てい的てき
決定的 means decisive or conclusive without implying harm, while 致命的 specifically means fatal or ruinous, so the two are easily confused when both modify words like ミス or 一撃.
致ち命めい傷しょう
致命的 is the na-adjective meaning 'fatal, critical' describing a situation, while 致命傷 is the noun for the actual fatal wound itself.

Compound of 致命 (fatal, from 致 'to cause' and 命 'life') and the adjectival suffix 的. The word is a Sino-Japanese formation.