out of tune; off-key; discordant; false note
Describes music or singing that is off-key, or metaphorically something that is out of step or not fitting in. Can be used as a noun or na-adjective.
See also: 調子っぱずれ (ちょうしっぱずれ)
His singing was off-key and painful to listen to.
At the meeting, he was the only one who made a discordant remark.