骨身 (ほねみ, honemi) Japanese meaning: flesh and bones | KotomoraFreq.FrequencyTop 100,000 Expressions
骨身にしみるfeel keenly; strike to the core; hit home · pierce deep inside (of cold) 骨身を惜しまずsparing no effort; tirelessly; painstakingly 骨身を惜しまないspare no effort; work tirelessly; give one's all
He worked tirelessly, sparing no effort.
骨
Etymology
Compound of 骨 (bone) and 身 (body/flesh), literally 'bone and flesh', used figuratively to mean one's whole physical and spiritual being.