もちろん、手伝いますよ。
Of course I'll help you.
I naturally thought he would come.
He can speak not only English but also French.
"Could you help me?" "Of course."
Not to mention studying, exercise is also important.
もちろん readily agrees with an obvious point ('of course'), whereas 確かに acknowledges the truth of a statement, often before adding a qualification.
もちろん states plainly that something is 'of course' true, whereas 疎か（おろか）specifically contrasts a lesser case with a greater one via 〜はおろか〜も.