難なん治じ

noun, noun which may take the genitive case particle 'no'

intractable; hard to cure

Primarily used in medical contexts to describe diseases or conditions that are difficult to treat or resistant to therapy.

• この病びょう気きは難なん治じで、治ち療りょうに長ながい時じ間かんがかかる。

  This disease is intractable and takes a long time to treat.

• 難なん治じ性せいのガンに対たいする新あたらしい治ち療りょう法ほうが開かい発はつされた。

  A new treatment for refractory cancer has been developed.

noun, noun which may take the genitive case particle 'no'

rebellious; obstinate; refractory

Describes a person or attitude that is stubbornly resistant to control or authority; less common than the medical sense.

• 彼かれは難なん治じな性せい格かくで、誰だれの言いうことも聞きかない。

  He has an obstinate personality and won't listen to anyone.