Usage patterns
〈場所〉が不潔だa place is dirty/unsanitary
This bathroom is very unsanitary.
不潔な話an indecent/dirty story or joke
He always tells dirty jokes to make people laugh.
不潔な〈物〉a dirty/unclean thing (e.g. hands, room)
You shouldn't touch food with dirty hands.
〈物〉を不潔にするto make something dirty/unsanitary
Leaving trash around makes the room unsanitary.