large store; big shop
Refers to a physically large or well-established retail store, often contrasted with smaller local shops.
A new large store opened in front of the station.
He ran a large store in Edo.
Large stores line this street.
The master of the big store was well known around town.
小売店 is a neutral term for a retail outlet of any size, while 大店 stresses that the shop is large-scale.
小店 is a small, modest shop, the direct opposite in scale to a 大店.
Compound of 大 (おお, 'large') and 店 (たな, 'store, shop'). The reading たな for 店 is an older native Japanese reading, while みせ is more common in modern Japanese.