godan verb (-ku), transitive verb
leave as is; let alone; disregard
Used when someone or something is intentionally left out, ignored, or passed over, often in favor of another person or action. Commonly appears in the negative 差し置いて to mean 'without regard for' or 'setting aside'.
He went ahead and decided on his own, disregarding his boss.
そんな大事な問題を差し置いておくわけにはいかない。
We can't just leave such an important issue unattended.