Describes a state of deep unhappiness, wretchedness, or pitifulness, often with a nuance of self-pity or objective misery.
I felt miserable after getting caught in the rain.
彼は惨めな生活を送っていた。
He led a wretched life.
I felt miserable after losing the match.
The team suffered a miserable defeat.
He stood there in a pitiful state, soaked by the rain.
Poverty made him feel miserable.
惨め describes a person's own subjective feeling of wretchedness, while 悲惨 objectively describes how dire an external situation or event is.