Usage patterns
不幸に見舞われるto be struck by misfortune
That family was struck by one misfortune after another.
〈人〉にご不幸があるfor someone to suffer a bereavement (death in the family)
Since my friend had a death in the family, I sent flowers.
不幸な人生を送るto lead an unhappy life
She has led an unhappy life.
不幸を招くto invite / bring about misfortune
That decision brought about later misfortune.
Expressions
不幸にもunfortunately; unluckily; regrettably 不幸中の幸いsmall mercy in misfortune; silver lining; blessing in disguise 不幸にしてunfortunately; regrettably; sad to say 幸か不幸かfor better or worse; luckily or unluckily