Usage patterns
〈事〉に意義があるthere is significance/meaning in (doing) something
This research has great significance.
〈事〉の意義を認めるto acknowledge the significance of something
He acknowledged the significance of that activity.
意義を見出すto find meaning/significance (in something)
She finds meaning in her work.
〈事〉の意義を問うto question the significance or purpose of something
Voices are rising questioning the significance of this system.