expression, ichidan verb
be disgusted with; be fed up with; run out of patience with
Expresses that one's goodwill or patience toward someone has been exhausted, often due to repeated bad behavior. The subject is the person whose patience is lost, and the target is marked with に.
彼のわがままには愛想が尽きた。
I'm fed up with his selfishness.
何度も嘘をつかれて
After being lied to so many times, I've completely run out of patience with her.