destination (of a journey by plane or boat)
Refers specifically to the destination of a trip involving air or sea travel, often used in travel contexts.
Let's check the weather at the destination beforehand.
I heard his destination is Hawaii.
目的地 is a broader term for any destination, not limited to travel by plane or boat.
Compound of 渡航 (tokō, 'voyage' or 'crossing by sea/air') and 先 (saki, 'destination' or 'ahead').