Refers to the place one is heading toward, whether a physical location or a figurative objective.
次の目的地は京都です。
Our next destination is Kyoto.
人生の目的地を見失ってしまった。
I've lost sight of my goal in life.
Because the destination is deep in the mountains, the road is rough.
We'll probably arrive at our destination by evening.
We set off heading toward our destination.
There are still ten more kilometers to the destination.
I set the destination on the car navigation system before starting to drive.