Usage patterns
〈場所〉に目的地があるthe destination is located at [place]
Because the destination is deep in the mountains, the road is rough.
目的地に着くto arrive at one's destination
We'll probably arrive at our destination by evening.
目的地に向かうto head toward one's destination
We set off heading toward our destination.
目的地までの距離the distance to one's destination
There are still ten more kilometers to the destination.
目的地を設定するto set a destination (e.g. in a GPS or navigation system)
I set the destination on the car navigation system before starting to drive.