noun, noun which may take the genitive case particle 'no'
Used attributively with 通り, 場所, 商店街, etc., to describe a prominent, bustling, or fashionable street or area. Often implies a central, well-known location.
This street is the main street of the town.
A new shop opened in a prime location.
The main shopping street in this town is always bustling with people.
The new store opened in a prominent, central location.
目抜き describes a bustling, central, well-known area, while 場末 describes an obscure, out-of-the-way district on the edge of town.
繁華街 refers to a whole busy downtown or entertainment district, while 目抜き describes a single prominent street or spot within such an area.
main street; principal street; thoroughfare
Compound of 目 (eye, attention) and 抜き (pulling out, extracting). The image is of a place that 'catches the eye' or stands out prominently, hence a main or fashionable thoroughfare.