obstacle; hindrance; impediment
Refers to a person or thing that physically or metaphorically blocks progress or makes something difficult.
He is an obstacle to the project.
Describes a person who is annoying, in the way, or a bother to others; often used in social contexts.
This big rock is an obstruction on the road.
He's a nuisance who always interrupts people.
Making such a racket at the party, he's a real burden.
邪魔 is a more general noun/suru-verb meaning hindrance or disturbance, while 邪魔者 specifically refers to a person or thing that is a hindrance.
お邪魔虫 is a colloquial, slightly self-deprecating term for a person who intrudes or is a nuisance, often used about oneself.
邪魔者 is someone who gets in the way or hinders, the opposite of a 助っ人 who comes to help.
Standard kanji spelling.
Variant kanji spelling; 物 can be used for a person or thing that is a hindrance.
Compound of 邪魔 (じゃま, hindrance) and 者 (もの, person). The variant 邪魔物 uses 物 (もの, thing) to include non-human obstacles.