Usage patterns
骨格が〈形容詞〉to have a (certain kind of) build or frame
He has a big, sturdy build.
〈事〉の骨格を作るto draft the basic framework of (a plan, story, etc.)
First draft the skeleton of the paper, then work out the details.
骨格を固めるto firm up or finalize the basic framework of a plan, policy, etc.
They finalized the basic framework of next year's budget proposal.
骨格が歪むfor one's skeletal structure to become misaligned or distorted
Poor posture can cause your skeletal structure to become misaligned.