別べっ荘そう

別べっ宅たく sense 1
別荘 specifically means a vacation home in a resort or rural area, while 別宅 is a broader term for any second residence, not necessarily for leisure.
別べっ邸てい sense 1
別邸 is a formal, often grander term for a separate residence, whereas 別荘 is the everyday word for a vacation home.
山さん荘そう sense 1
山荘 refers specifically to a mountain lodge or cabin, while 別荘 covers any vacation home regardless of location.
寮りょうN4
別荘 is the modern standard word for a villa or country house, replacing the archaic villa sense of 寮.

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ビラ
別荘 is the general Japanese word for any privately owned holiday home, while ビラ suggests a stylish, resort-style Western villa.
荘しょう
別荘 is the everyday word for a vacation villa or second home, while 荘 alone is a more formal or historical term for a manor or villa.
コテージ
別荘 refers to a second home for vacations that is often larger and more permanent, while コテージ is a small, simple cottage-style house.
保ほ養よう所じょ
別荘 is a privately owned vacation home for an individual or family, while 保養所 is a facility maintained by a company or group for its members.

Opposites

本ほん宅たく sense 1
本宅 is one's main, permanent residence, in contrast to 別荘, a secondary home used only occasionally.

棟むね
Counts whole buildings (one roof); the everyday native reading.
棟とうN1
Counts whole buildings; the formal reading used in official contexts like real-estate listings and hospitals.

Compound of 別 (separate, another) and 荘 (villa, manor). The colloquial prison sense is a sarcastic extension of the 'vacation home' meaning.