Honorific term used to refer to someone else's wife, or to address a married woman politely. Not used for one's own wife.
The wife next door is very kind.
奥さん、お元気ですか。
How are you, madam?
Please give my regards to your wife.
How is Mr. Tanaka's wife doing?
奥さん is the polite term used for someone else's wife, while 嫁さん is a casual term that can refer to one's own or a close friend's wife.
奥様 is the more formal, elevated term for someone's wife, while 奥さん is the everyday polite version used in casual conversation.
奥さん is the polite, honorific way to refer to someone else's wife, while 女房 is used only for one's own wife and never politely about another person's.